Cancer Research: The Beginning

By Jason Myers

In 1938, the cancer scientist and researcher Paul Gerhardt Seeger, M.D., disclosed that the true culprit of the cancerous degeneration of a cell is traced from from the destruction of a specific respiratory enzyme, cytochrome oxidase. In other words, cell malignancy is caused by disruption of oxygen utilization, or cell respiration.

Dr. Seeger fulfilled experiments with hundreds of histo-chemical methods in the Department of Cell and Virus Research in the Robert Koch Institute of Berlin, Germany. Later work at Humbolt University in Berlin in 1956, after around 10 years of work at Charite Hospital, affirmed his earlier research results of 1938. What Dr. Seeger discovered was that deactivation or damage of the enzyme cytochrome oxidase triggers a dysfunction of the metabolism in the early phases of the generation of energy in the mitochondria.

Mitochondria accomplish their role of producing energy through an oxygen intensive process known as oxidative phosphorylation. Resulting from a series of biochemical reactions, carbohydrates, fats, and proteins are chopped down into smaller units. Carbon dioxide and hydrogen are discharged along the way. The carbon dioxide, a type of toxic waste, is rapidly removed. The hydrogen ion is carried by the electron transport chain, ultimately blending with molecular oxygen to form water. The energy sourced out from our food components is then saved in the form of a universal energy molecule called adenosine-triphosphate (ATP).

When the enzyme cytochrome oxidase is inactivated or extinguished, excess hydrogen accumulates in the cell as oxidative phosphorylation comes to a stop. The cell still needs energy, however, and is drawn to shift over to a less efficient method of energy synthesis taking place in the area around cytoplasm. This results in the transformation of only about 20% of the potential energy that could be available, and only about 1/5 of possible ATP storage. Low energy is generated for the cell's usage, and less energy is stored.

With the cell's main energy generators, syntheses now greatly diminished, laying down the foundation for cancerous degeneration. Any issues concerning the operation and functioning of the mitochondria have a bad implication on all energy-requiring functions of our body. More than just the cell in which the malfunctioning mitochondria is situated can be affected, the lower energy level can affect other organs, or even the entire body. - 30427

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